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Microfluidic & nanofluidic technologies for chemistry, physics, biology, and bioengineering
Cover Gallery
Microfluidic distillation is made possible using capillary forces and segmented flow. The cover illustrates that separation is realized in component microfluidic systems as well as on a single chip.
Image reproduced by permission of Klavs Jensen.DOI: 10.1039/B901790A
Fluorescent Activated Droplet Sorting (FADS) enables microfluidic-based high-throughput selection of single microorganisms based on their enzymatic activity. Image reproduced by permission of Andrew Griffiths.
DOI: 10.1039/B910847P
A high-throughput, comtamination-free, chip-to-chip nanoliter microfluidic dispenser is demonstrated to perform the accurate dispensation of liquid samples from tens to hundreds of nanoliters, indicating the high flexibility and wide applications of this novel system. Image reproduced by permission of Yuanyi Huang
DOI: 10.1039/B910852C
Complex 3D structures are generated via optofluidic maskless lithography in a membrane-mounted microfluidic channel. In this way, heterotypic cells can be patterned in hydrogels in 3D morphologies.. Image reproduced by permission of Sunghoon Kwon
DOI: 10.1039/B819999J
High-radix microfluidic multiplexer selectively addressing bio-samples to 4×4 well array with pressure valves of the different thresholds in a few control lines. Image reproduced by permission of Young-Ho Cho.
DOI: 10.1039/B909825A
Actuate-to-Open valves enabled the creation of a microfluidic array chip comprised of picoliter-sized wells with integrated photonic crystal biosensors for combinatorial mixing and subsequent on-chip screening for biomolecular binding events.Image reproduced by permission of Paul Kenis
DOI: 10.1039/b909828n
A polymer chip with an array of ordered pillars for separations via pressure-driven liquid chromatography. Image reproduced by permission of Albert Romano-Rodriguez
DOI: 10.1039/B818918H
Electrolysis-bubble-based micropump using air bubbles to drive microfluidics/blood has features of room-temperature operation and low driving voltage/power consumption without changing the properties of the sample liquid. On-chip blood transportation is demonstrated using this embedded micropump. Image reproduced by permission of Cheng-Hsien Liu
DOI: 10.1039/B908904g
Fresh out of production. A 3 x 7 cm fused silica microchip containing four horizontal 500 µm wide microchannels and 32 vertical 460 nm deep nanochannels photographed in the clean room after bonding. Image reproduced by permission of Takehiko Kitamori
DOI: 10.1039/B908908j
Delay-lines allow the incubation of microfluidic droplets in the minute to hour range directly onchip. The concepts presented overcome limitations concerning back-pressure and unequal incubation times. Image reproduced by permission of Tobias Frenz.
DOI: 10.1039/B816049J
Illustration of a curved Airy laser beam which conveys microparticles and cells over walls within a microfluidic chip. Image reproduced by permission of Joerg Baumgartl.
DOI: 10.1039/B907825H
A travelling wave dielectrophoretic pump is simply a micro channel with an electrode array, and is ideal for blood delivery since the inherent cells are served as the media for exchanging momentum between electricity and fluid mechanics. Image reproduced by permission of U. Lei.
DOI: 10.1039/B907829K
Pathogens (green) in blood (red) are magnetically opsonized (blue) before entering the micromagnetic-microfluidic blood cleansing device and magnetically pulled into a laminar stream of saline (clear) for removal. Image reproduced by permission of Donald Ingber.
DOI: 10.1039/B816986A
A micro optofluidic lens formed in a circular chamber was developed by Nguyen's group from Nanyang Technological University, Singapore. Image reproduced by permission of Nam-Trung Nguyen.
DOI: 10.1039/B906131M
Cells and functionalized microbeads have been arranged by manipulation based on electrophoresis and stabilized within a specific microwell electrode (MWE) in a continuous flow. The cell secretion, immunological and genetic reaction can be electrochemically detected by the MWE. Image reproduced by permission of Tomokazu Matsue and Hsien-Chang Chang.
DOI: 10.1039/B906134G
Hybrid microfluidics in action: fluorescent droplets march down an array of electrodes toward a network of microchannels for separation. Image reproduced by permission of Aaron Wheeler.
DOI: 10.1039/B820682A
On-chip DNA methylation analysis using methylation-specific PCR (MSP) within an arrayed microdroplet-in-oil platform. Image reproduced by permission of Tza-Huei Wang.
DOI: 10.1039/B905244P
3D microfiltration device within a microfluidic network is fabricated by the reported direct projection on dry-film photoresist process. Image reproduced by permission of Tingrui Pan.
DOI: 10.1039/B905247J
Mass production of regulatorycompliant microfluidic devices for clinical diagnostic. Image reproduced by permission of Daniel Chiu.
DOI: 10.1039/B818873D
A soup of composite particles prepared by lock release lithography (LRL) that provides a means for the high-throughput production of particles with complex 3D morphologies and composite particles with spatially configurable chemistries. Image reproduced by permission of Patrick Doyle.
DOI: 10.1039/B904077N
Frequency-modulated ultrasound can be used for aggregation, flow-free transport and caging of microparticles or cells in a microfluidic chip. Micrographs (left column) show caging and transport of 5-mm green beads. Particle image velocimetry diagrams (right column) for fluid flow tracking with 1-mm yellow beads. Image reproduced by permission of Otto Manneberg.
DOI: 10.1039/B816675G
Double fluorescence viability staining of the cardiac cells located in part of a microchannel upon exposure to a concentration gradient of cardiac toxin generated by the microfluidic device. Image reproduced by permission of Ali Khademhosseini.
DOI: 10.1039/B903259M
A macromolecule that specifically binds a protein and initiates polymerization upon absorbing light was used to detect and subtype the influenza virus. The readout in this assay is a crosslinked polymer. Image reproduced by permission of Christopher Bowman.
DOI: 10.1039/B816198D
A multi point force sensor array based on holographic optical tweezers has been integrated into a microfluidic device to investigate chemo-mechanical interactions of biomimetic actin networks. Image reproduced by permission of Joachim Spatz.
DOI: 10.1039/B901946B
New capillary microreactors incorporating catalytic nanoparticles confined in a mesoporous wall coating show great promise in selective hydrogenation chemistry.
DOI: 10.1039/B815716B
A photograph of a fluidic device making it possible to study directional angiogenesis in response to defined molecular gradients. Superimposed is a vascular plexus (shown in red) with induced directional sprouting.
DOI: 10.1039/B901062A
Using an adaptation of single-level isotropic wet etching, small shallow micropores are radially embedded in larger deeper microchannels for cell concentration, immobilization, and picodroplet generation.
DOI: 10.1039/B901067J
Micrograph of a solution of unlabelled double-stranded DNA, electrophoretically concentrated near a 50 mm-wide electrode.
DOI: 10.1039/B821774M
A microarray of 816 laserilluminated surface plasmon resonance imaging pixels. Each sub-micron pixel is a 3-by-3 nanohole array with surrounding Bragg mirrors, giving enhanced sensitivity and pixel-to-pixel isolation.
DOI: 10.1039/B822886H
An LCD image projected onto the photoconductive surface induces frequency-dependent AC electrokinetics, resulting in the rapid and selective microparticle concentration in an optoelectrofluidic platform.
DOI: 10.1039/B811740C
An integrated microfluidic device is developed for the characterization of drug metabolites and the assessment of their cytotoxicity simultaneously.
DOI: 10.1039/B822016F
Coupling of an enzymatic magnetobioreactor with on-chip amperometric detection can lead to extremely low limits of detection in the determination of carbofuran and other toxic substances by enzymatic inhibition.
DOI: 10.1039/B822019K
The 'Dropspots' device is used to generate arrays of drops. Cells producing the enzyme are encapsulated in drops with the fluorogenic substrate. The color gradient shows enzyme activity varies in each drop with the cell count.
DOI: 10.1039/B809670H
Femtosecond lasers are powerful tools to directly inscribe optical waveguides in lab-on-a-chips. In this way on-chip optical detection is achieved in view of compact and portable devices.
DOI: 10.1039/b821102g
A simple, robust and low dead volume world-to-chip interface for thermoplastic microfluidics employing stainless steel needles has been developed. Using interference fit and threaded needles, the simple needle ports are compatible with internal chip pressures above 40 MPa with negligible dispersion for injected analyte bands.
DOI: 10.1039/b821105c
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