Integrative Biology

A new journal of quantitative biosciences from nano to macro

Latest News

Revealing the factors behind liver disease

12 August 2009

Array system tests hundreds of conditions to find those that lead to liver damage

A PDMS device and cells migrating through the device with time

30 July 2009

Unexpected results challenge established beliefs about metastasis

Abstract image of bright lines on a dark background

14 July 2009

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Advance Articles

Contents list for Integrative Biology, issue 10, 2009

Front cover
Integr. Biol., 2009, 1, 557
DOI: 10.1039/b918974m

front cover image for Integrative Biology, Issue 10, 2009

Contents
Integr. Biol., 2009, 1, 559
DOI: 10.1039/b918975k

Tutorial Review

FRET and mechanobiology
Yingxiao Wang and Ning Wang,� Integr. Biol., 2009, 1, 565
DOI: 10.1039/b913093b
RSC Prospect Icon Enhanced HTML article available

graphical abstract image (ID: b913093b)

A cartoon scheme depicting the application of FRET biosensors in detecting mechanotransduction. When the cells are mechanically activated, biosensors can undergo a conformational and FRET change.

Critical Review

Microfluidic sample preparation: cell lysis and nucleic acid purification
Jungkyu Kim, Michael Johnson, Parker Hill and Bruce K. Gale,� Integr. Biol., 2009, 1, 574
DOI: 10.1039/b905844c
RSC Prospect Icon Enhanced HTML article available

graphical abstract image (ID: b905844c)

A review of DNA and RNA sample preparation techniques from cell lysis to nucleic acid purification and how they advance on-chip microfluidic nucleic acid analysis towards widespread applications

Papers

Parylene peel-off arrays to probe the role of cell�cell interactions in tumour angiogenesis
Christine P. Tan, Bo Ri Seo, Daniel J. Brooks, Emily M. Chandler, Harold G. Craighead and Claudia Fischbach,� Integr. Biol., 2009, 1, 587
DOI: 10.1039/b908036h
RSC Prospect Icon Enhanced HTML article available

graphical abstract image (ID: b908036h)

We have developed a simple and reproducible micropatterning approach utilising parylene peel-off templates to spatiotemporally control cell�cell interactions and study their role in tumour angiogenesis.

Cell�cell communication between adipocytes and pancreatic -cells in acoustically levitated droplets
Sabina Santesson, Eva Degerman, Patrik Rorsman, Thomas Johansson, Sandra Lemos and Staffan Nilsson,� Integr. Biol., 2009, 1, 595
DOI: 10.1039/b907834g
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graphical abstract image (ID: b907834g)

Development of advanced airborne technology for the analysis of single cell response and investigation of cell�cell communication events. With application to cell interaction and behavior within different stimuli and inhibitors.

Millisecond timescale slimfield imaging and automated quantification of single fluorescent protein molecules for use in probing complex biological processes
Michael Plank, George Howard Wadhams and Mark Christian Leake,� Integr. Biol., 2009, 1, 602
DOI: 10.1039/b907837a
RSC Prospect Icon Enhanced HTML article available

graphical abstract image (ID: b907837a)

A novel slimfield illumination technology now permits imaging of single fluorescent protein molecules at an exceptionally high time resolution of only a few milliseconds.