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A different approach to stem cell research
02 December 2008
Studies reveal what makes stem cells change and how to make them stay the same
Instant insight: Digging deep with microtools
01 December 2008
Jaime Castillo, Maria Dimaki and Winnie E. Svendsen explain how micro and nano manipulation techniques are helping researchers understand biological systems
Interview: Integrative biology
26 November 2008
Mina Bissell talks to Kathleen Too about the concept and future of integrative biology
Contents list for Integrative Biology, issue 1, 2009
Front cover
Integr. Biol., 2009, 1, 1
DOI: 10.1039/b822121a
Inside front cover
Integr. Biol., 2009, 1, 2
DOI: 10.1039/b822122g
Contents and Chemical Biology
Integr. Biol., 2009, 1, 3
DOI: 10.1039/b822125c
Editorials
Only connect
(E. M. Forster)
Integr. Biol., 2009, 1, 13
DOI: 10.1039/b819961m
A brief foreword by Mina Bissell, Editorial Board Chair.
Integrating biology and technology
Integr. Biol., 2009, 1, 14
DOI: 10.1039/b818604a
Scientific Editors Mary Helen Barcellos-Hoff and David Beebe introduce the first issue of Integrative Biology.
Profile
Integrative Biology Editorial Board members
biographies
Integr. Biol., 2009, 1, 15
DOI: 10.1039/b818898j
Integrative Biology profiles members of the Editorial Board.
Focus
Integration column: Microfluidic high-throughput screening
Sebastian J. Maerkl,
Integr. Biol., 2009, 1, 19
DOI: 10.1039/b819762h
Enhanced HTML article available
Sebastian Maerkl discusses the various approaches for biomedical, biophysical and cell-based assays using high-throughput screening experiments on chip—part of a series of mini-reviews covering integration of new tools and technologies for the benefit of biology.
Critical Reviews
Manipulation of biological samples using micro and nano techniques
Jaime Castillo, Maria Dimaki and Winnie Edith Svendsen,
Integr. Biol., 2009, 1, 30
DOI: 10.1039/b814549k Enhanced HTML article available
Different techniques available to manipulate biological samples in a controlled manner are reviewed. The advantages and drawbacks are discussed together with examples that reflect the state of the art.
Raman tweezers and their application to the study of singly trapped eukaryotic cells
Richard D. Snook, Timothy J. Harvey, Elsa Correia Faria and Peter Gardner,
Integr. Biol., 2009, 1, 43
DOI: 10.1039/b815253e Enhanced HTML article available
Raman tweezers can be used to trap and probe single biological cells in order to characterise them and their biochemical make up, making the technique valuable for studying diseases such as cancer.
Minireview
Advances and perspectives in aptamer arrays
William Rowe, Mark Platt and Philip J. R. Day,
Integr. Biol., 2009, 1, 53
DOI: 10.1039/b815539a Enhanced HTML article available
The latest developments in the quantification of analytes using aptamer microarrays are reviewed, highlighting their potential in the characterization of biological systems.
Papers
Perturbation of single hematopoietic stem cell fates in artificial niches
Matthias P. Lutolf, Regis Doyonnas, Karen Havenstrite, Kassie Koleckar and Helen M. Blau,
Integr. Biol., 2009, 1, 59
DOI: 10.1039/b815718a Enhanced HTML article available
Microarrayed 
artificial niches for single hematopoietic stem cells reveal role of individual niche components in stem cell self-renewal.
Human mammary progenitor cell fate decisions are products of interactions with combinatorial microenvironments
Mark A. LaBarge, Celeste M. Nelson, Rene Villadsen, Agla Fridriksdottir, Jason R. Ruth, Martha R. Stampfer, Ole W. Petersen and Mina J. Bissell,
Integr. Biol., 2009, 1, 70
DOI: 10.1039/b816472j Enhanced HTML article available
Determining how stem cells (yellow) integrate combinatorial instructions from microenvironments to yield differentiated luminal (green) and myoepithelial (red) cells is a fundamental question requiring parallel combinatorial cell biology.
Mapping mammary gland architecture using multi-scale in situ analysis
Rodrigo Fernandez-Gonzalez, Irineu Illa-Bochaca, Bryan E. Welm, Markus C. Fleisch, Zena Werb, Carlos Ortiz-de-Solorzano and Mary Helen Barcellos-Hoff,
Integr. Biol., 2009, 1, 80
DOI: 10.1039/b816933k Enhanced HTML article available
We developed novel image analysis tools and used Monte Carlo simulations to characterize putative progenitor cells in situ, which revealed their novel distribution as a function of murine mammary architecture.
Real-time detection of the early event of cytotoxicity of herbal ingredients on single leukemia cells studied in a microfluidic biochip
XiuJun Li, Xiaoyan Xue and Paul C. H. Li,
Integr. Biol., 2009, 1, 90
DOI: 10.1039/b812987h Enhanced HTML article available
A microfluidic approach has been developed for fast and real-time detection of cytotoxicity of drug candidates on single cancer cells, based on the measurement of sustained increase in the cytosolic calcium ([Ca2+]i).
Genome-wide transcriptome analysis of 150 cell samples
Daniel Irimia, Michael Mindrinos, Aman Russom, Wenzhong Xiao, Julie Wilhelmy, Shenglong Wang, Joe Don Heath, Nurith Kurn, Ronald G. Tompkins, Ronald W. Davis and Mehmet Toner,
Integr. Biol., 2009, 1, 99
DOI: 10.1039/b814329c Enhanced HTML article available
We have designed a system for the purification of total cellular RNA and utilized it with a powerful linear whole transcriptome amplification protocol to accomplish a highly reproducible and robust genome wide expression analysis from as few as 150 cells.
Influence of applied currents on the viability of cells close to microelectrodes
Michael Gabi, Takumi Sannomiya, Alexandre Larmagnac, Manjunath Puttaswamy and Janos Vörös,
Integr. Biol., 2009, 1, 108
DOI: 10.1039/b814237h Enhanced HTML article available
The current-dependent electrochemically induced pH change was measured close to microelectrodes and its effect on viable cells was investigated.
Analysis of aptamer sequence activity relationships
Mark Platt, William Rowe, Joshua Knowles, Philip J. Day and Douglas B. Kell,
Integr. Biol., 2009, 1, 116
DOI: 10.1039/b814892a Enhanced HTML article available
Aptamer sequence–function relationship is explored using high density DNA microarrays. Collected data form a model that describes key motifs for quadruplex formation.
Integrative systems control approach for reactivating Kaposis sarcoma-associated herpesvirus (KSHV) with combinatory drugs
Chien-Pin Sun, Takane Usui, Fuqu Yu, Ibrahim Al-Shyoukh, Jeff Shamma, Ren Sun and Chih-Ming Ho,
Integr. Biol., 2009, 1, 123
DOI: 10.1039/b815225j Enhanced HTML article available
With a system control technology, we can rapidly identify the optimal combinatorial stimulations to direct cell as an integrative biological system toward a desired phenotype.
Back cover
Integr. Biol., 2009, 1, 131
DOI: 10.1039/b822126j
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